Leukemia

Acute Promyelocytic Leukaemia (APL) is a rare and highly aggressive condition, once considered the most severe and incurable acute myeloid leukaemia (AML). Since its initial description in the 1950s, significant progress has been made in understanding the disease, including the identification of the leukemic transformation process, the t(15;17) translocation, and the rearrangement of the retinoic acid receptor alfa (RARA) with the PML gene in the 1970s.